Pharmacokinetics is an important part of the research on druggability of innovative drugs. The absorption, distribution, metabolism, and excretion of drugs are closely related to drug efficacy and safety. We have laboratories that meet international standards, a variety of advanced in vivo and in vitro experimental techniques and biological analysis devices. With years of experience in pharmacokinetic studies in multiple therapeutic areas or drug targets, the team leader and core R&D staff can provide a holistic approach and complete set of R&D services from early in vitro absorption, distribution, metabolism and excretion (ADME) screening to in vivo pharmacokinetic evaluation (PK) in experimental animals. Our goal is to provide fast, effective and high quality research solutions to meet the needs of the customers in ADME studies, and help customers reduce R&D costs and increase the success rate of new drug development according to their project requirements.

Services for in vitro ADME studies

  • Drug solubility and chemical stability studies
  • Stability studies of drugs in hepatic microsomes (human, mouse, dog, monkey, etc.), S9, cytoplasmic fluid or hepatocytes
  • Stability studies of drugs in plasma, serum or whole blood
  • Caco-2 or MDCKII- MDR1 permeability studies
  • Efflux and uptake transporter (substrate or inhibitor) studies
  • P450 enzyme inhibition (reversible or time-dependent) studies
  • P450 enzyme induction studies
  • P450 enzyme (recombinant enzyme) metabolic phenotype studies
  • UGT enzyme inhibition
  • Identification of metabolites and analysis of metabolic pathway in in vitro systems (in hepatic microsomes, S9, cytoplasmic fluid or hepatocytes)
  • Reactive intermediate glutathione capture (GSH-Adduct) studies

Services for in vivo PK studies

  • Establishment and validation of LC-MS/MS analytical methods
  • Pre-formulation research and evaluation
  • Bioavailability (IV, PO) evaluation in a variety of animal species (rats, mice, dogs, monkeys, etc.)
  • Kinetic evaluation of different routes of drug administration (intravenous, oral, intraperitoneal, subcutaneous and intramuscular, etc.)
  • Tissue distribution and measurement of drug concentrations in a variety of biological samples (plasma, whole blood, urine, feces, bile, and various tissues)
  • Analysis of drug excretion pathways (BDC rat urine, bile, etc.) and identification of metabolites in vivo
  • Address

    Bldg. 12, No. 59 Kai Qing Rd, Pudong, Shanghai (West Campus)

    Bldg. 7, No. 509 Ren Qing Rd, Pudong, Shanghai (East Campus)

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