Pharmacokinetics (PK) is an important aspect of research for the druggability evaluation of innovative drugs, closely related to the ADME profile (Absorption, Distribution, Metabolism, Excretion),and also the efficacy or safety of drugs. Depending on internationally standardized laboratories, mature in-vitro / in-vivo experimental techniques, advanced bioanalytical equipment, and also experienced team leaders and core researchers which are dedicated to pharmaceutical research for many years, Pharmaresources (PR) can provide a comprehensive research approach and a complete set of development services covering multiple therapeutic areas or targets throughout the early in vitro ADME screening to in vivo pharmacokinetic evaluation in experimental animals. Our goal is providing fast, effective, and high-quality research solutions based on the specific requirements of clients, meeting their needs in the ADME field, assisting them in reducing development costs, and increasing the success rate of new drug development.

In vitro ADME research Services:

  • Solubility and Chemical stability study
  • Stability study in liver microsomes (human, mouse, dog, monkey etc), liver S9, cytoplasmic fluid and hepatocyte
  • Stability study in plasma, serum or whole blood
  • Permeability study: Caco-2 or MDCK-MDR1
  • Efflux and uptake transporter (substrate or inhibitor) study
  • CYP P450 enzyme inhibition (reversible or time-dependent) and induction study
  • CYP P450 enzyme metabolic phenotype study
  • UGT enzyme inhibition study
  • Met-ID study (liver microsome, S9, cytoplasmic fluid and hepatocyte)
  • Study of Glutathione trapping reactive intermediates

In vivo PK research Services:

  • Establishment and validation of LC-MS/MS analytical methods
  • Pre-formulation evaluation
  • Bioavailability (IV, PO) evaluation in variety of animal species (mice,rat, dog, monkey etc.)
  • PK evaluation through different routes of administration (IV, PO, IP, SC, IM etc.)
  • Tissue distribution and determination of drug concentrations in various biological samples (plasma, whole blood, urine, feces, bile and various tissues)
  • Analysis of drug elimination pathways (BDC rat urine, bile etc) and identification of metabolites
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