Process development platforms

Process technology platforms

Solid state chemistry platforms

  • Have a professional and experienced team;
  • Have a key instrumentation and platform for long-term collaboration to meet solid-state chemical process development
  • Easymax
  • Polarized light microscope
  • XRPD
  • DVS
  • DSC
  • TGA

Salt/crystal form screening

  • API/salt form
  • Solubility
  • Crystallinity
  • Chemical stability
  • Melting point
  • Physical stability
  • Hygroscopicity
  • Solids characterization

Crystallization process development

  • Solubility
  • Drying
  • Crystal habit
  • Solvent residue
  • Particle size
  • Flowability
  • Filtering

Solid-state chemistry platform - crystallization process

  • Process for the preparation of sodium salt crystal I: suspend the raw material in 10 V toluene at room temperature and then add 1.1 equivalents of 1 M aqueous sodium hydroxide to the suspension;
  • Successfully scale up the crystallization of sodium salt dihydrate according to this preparation process
  • Solvents and alkali
    Solvent (Vol.): toluene (10V)
    Alkali (eq): NaOH (1.1)
  • Step 1
    Add aqueous sodium hydroxide solution to
    make the suspension a clear solution
  • Step 2
    Stir the clarified solution at room temperature
    to precipitate the solid overnight
  • Results
    Target sodium salt crystal form
  • Address

    Bldg. 12, No. 59 Kai Qing Rd, Pudong, Shanghai (West Campus)

    Bldg. 7, No. 509 Ren Qing Rd, Pudong, Shanghai (East Campus)

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