Evaluation system of recombinant enzyme metabolism

▶  CYP1A2, CYP2B6, cyp2c8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, etc

▶  UGT1A1, UGT1A3, UGT1A6, UGT1A9, ugt2b4, UGT2B7, UGT2B17, etc

▶  Others: FMOS, Maos, CES, etc

Liver microsomes + chemical inhibitors

Evaluation of drug interaction based on CYP and UGT inhibition

▶  Reversible inhibition evaluation

▶  Time dependent (TDI) inhibition (or mechanism inhibition) evaluation